Through November 20, 2012
Studies on the role of reinforcement learning in both motor control and motivated behavior are at the forefront of neuroscience research and integrate approaches ranging from behavioral to molecular. Its significance is reflected in its relevance to our daily lives. Our behaviors are shaped by reward and punishment histories through reinforcement learning. Maladaptive reinforcement learning is implicated in many psychiatric and neurological disorders including addiction, depression, eating disorders, obsessive-compulsive disorder and Parkinson’s disease.
One of the important neural substrates for reinforcement learning is corticostriatal plasticity which will be a central topic of the symposium. Its modulation by dopamine and connected networks, its impact on basal ganglia function and on normal as well as maladaptive behaviors will be discussed.
The symposium will be divided into four sessions in two and half days. We will go from behavior, anatomy, neural circuits and cellular processes to molecular signaling. Besides formal presentations, we will have a lot of discussion time. Studies on reinforcement learning and basal ganglia function exemplify many of the important and challenging theoretical issues in neuroscience. We will have one open-ended discussion session devoted to two topics. In addition, we will limit each presentation to 20 min. We will leave the extra time to discussions and foster heated debates throughout the 3-day meeting.
Concrete goals of this symposium include:
The advancement of dopamine and basal ganglia research. The explosion of research in the field has created new challenges and opportunities. Bringing together top scientists in the field who have different views and approaches, integrating observations at different levels will bring new insights, especially in an intellectually stimulating atmosphere. One specific goal of the meeting is to identify key questions and controversies and propose research approaches to address them.
The facilitation of collaborations between meeting participants. Participants will be from different countries, research institutes and disciplines. The symposium is sponsored by the University of Chicago and co-sponsored by the Chinese National Institute on Drug Dependence, Peking University. The University of Chicago has a core group of investigators whose research focuses on dopamine and the basal ganglia (http://nida-training-program.bsd.uchicago.edu/faculty.html). The symposium will provide good opportunities for interactions between all participants and establishing future collaborations.
Organizers: Xiaoxi Zhuang (Department of Neurobiology, University of Chicago) and Lin Lu (Chinese National Institute on Drug Dependence, Peking University)
Conference Agenda (tentative)
9: 10:20 Reception and registration
10:20 Opening remarks
Session 1. Anatomical pathways and neuronal activities that support specific behaviors.
(Moderator: Paul Vezina, University of Chicago)
10:30 Bernard Balleine University of Sydney
Dopamine-opioid interactions in Pavlovian-instrumental transfer.
11:00 Henry Yin Duke University
Actions and goals: the integrative functions of the basal ganglia
11:30 Saleem Nicola Albert Einstein College of Medicine
Pedal to the metal: how nucleus accumbens dopamine activates flexible navigation towards reward
12:00 Paul Phillips University of Washington
Can dopamine comply to model-free learning algorithms and also regulate decision making?
12:30 Lunch (buffet at HuiXianFu Dining Hall on Renmin University Campus).
(Moderator: Jeff Beeler, University of Chicago)
2:30 Tony Grace University of Pittsburgh
Tonic and phasic dopamine transmission and the modulation of response selection.
3:00 Stan Floresco University of British Columbia
Dopaminergic and habenular modulation of risky choice
3:30 Nicolas Vautrell University of Sheffield
Dopamine made me do it but what did I learn?
4:00 John Salamone University of Connecticut
Effort-related effects of tetrabenazine: Implications for animal models of the motivational symptoms of depression
(Moderator: John Salamone, University of Connecticut)
5:00 Ralph Dileone Yale University
Cortico-limbic interactions and control of food intake
5:30 Bruce Hope NIDA
Characterizing neuronal ensembles in addiction-related behaviors
6:00 Lin Lu Peking University
Retrieval-extinction procedure to erase drug memories
6:30 Harriet deWit University of Chicago
Harmonizing human and nonhuman findings: acute behavioral effects of amphetamine.
7:00 Free time. Conclusion of Day 1
Session 2. Synaptic transmission and plasticity that support specific functions.
(Moderator: Dan McGehee, University of Chicago)
8:30 Susan Sesack University of Pittsburgh
Dopamine neuron regulation: connectivity upstream and downstream of the basal ganglia
9:00 Elyssa Margolis UCSF
Functional heterogeneity in subsets of midbrain dopamine neurons
9:30 Steve Rayport Columbia University
Dopamine neuron functional connectomics
10:00 Xiangdong William Yang UCLA
Genetic dissection of pathological basal ganglia circuitry
(Moderator: Paul Phillips, University of Washington)
11:00 David Lovinger NIAAA
Coordinated calcium signaling in the direct and indirect pathways and calcium transients in dopaminergic terminals
11:30 Dan McGehee University of Chicago
Modulation of corticostriatal plasticity by the cAMP pathway
12:00 Anatol Kreitzer UCSF
Striatal mechanisms underlying adaptive motor behaviors
12:30 Box lunch at the Center
(Moderator: Yan Dong, University of Pittsburgh)
1:30 Jeff Beeler University of Chicago
When plasticity goes bad: aberrant learning and Parkinson’s disease
2:00 Un Kang University of Chicago
The role of cholinergic interneurons in levodopa-induced dyskinesia of Parkinson’s disease
2:30 Joe Tsien Georgia Health Sciences University
Molecular and neural insights into habit learning disease
3:00 Ming Xu University of Chicago
Dopamine receptors and drug-induced reward learning
(Moderator: Harriet deWit, University of Chicago)
4:00 Marina Wolf Rosalind Franklin University
Plasticity of calcium-permeable AMPA receptors regulates cocaine craving
4:30 Yan Dong University of Pittsburgh
Synaptic reorganization in craving behaviors
5:00 Christian Luscher University of Geneva
Drug-evoked synaptic plasticity: from cellular mechanisms to circuit remodeling and addictive behavior
5:30 Leave for dinner at Quanjude Peking Duck Restaurant. Conclusion of Day 2
Session 3. Signaling pathways and therapeutic strategies for basal ganglia diseases
(Moderator: Ming Xu, University of Chicago)
8:30 Paul Vezina University of Chicago
Dopamine-glutamate signaling in the nucleus accumbens and the expression of stimulant sensitization
9:00 Ping Zheng Fudan University
Influence of chronic morphine exposure on dopamine D1 receptors
9:30 Zhuan Zhou Peking University
Cocaine preferentially potentiates fast releasable vesicle pool in mouse dopaminergic striatum in vivo
10:00 Lin Xu Kunming Institute of Zoology, Chinese Academy of Sciences
Deficiency of central 5-HT causes inflexible recall of an established morphine conditioned place preference
(Moderator: Lei Wang, Georgia Health Sciences University)
11:00 Bill Green University of Chicago
The role of palmitoylation in neurodegenerative diseases
11:30 Minmin Luo National Institute of Biological Sciences, Beijing
Behavioral and physiological functions of membrane guanylyl cyclase receptors
12:00 Xiaoxi Zhuang University of Chicago
Dopamine, economic decision making and thrifty genes
12:30 Kurt Rasmussen Ely Lilly
Therapeutic strategies for novel antipsychotics
1:00 Catered lunch at the center
Session 4. Open-ended discussions (with wine and beer!!!)
Topic 1. Dopamine and behavior: issues and controversies (Discussion leader: Saleem Nicola)
Topic 2. Plasticity in the striatum: roles in learning/memory and neurological/neuropsychiatric disorders (Discussion leader: David Lovinger)
Conclusion of Day 3.